Fibroids: What are the Causes, symptoms, and treatments

WHAT IS FIBROID?

Uterine fibroids (leiomyomas) are benign monoclonal tumours of smooth muscle, taking origin in the in-wall of the uterus (myometrium). They are usually multiple and can range in size from a few millimeters to massive growths of 20cm diameter and more.

OTHER NAMES FOR FIBROID

Fibroids are also known by the following names:

  • leiomyomas
  • myomas
  • uterine myomas
  • fibromas

HOW COMMON IS FIBROID?

They are the most common benign tumours in the uterus and are typically round well-circumscribed masses. By age 50, it is estimated that 70% of women will have one or more uterine fibroids, with around 30% of patients symptomatic and requesting treatment.

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WHAT CAUSES FIBROIDS?

The cause is largely unknown, but they are oestrogen- and progesterone-dependent tumours, very rare before the beginning of menstruation (menarche), but common in reproductive life, and frequently reduce in size after menopause 1.

It’s unclear why fibroids develop, but several factors may influence their formation which includes;

  • Hormones

Estrogen and progesterone are the hormones produced by the ovaries. They cause the uterine lining to regenerate during each menstrual cycle and may stimulate the growth of fibroids.

  • Family History

Fibroids may run in the family. If your mother, sister, or grandmother has a history of this condition, you may develop it as well.

  • Pregnancy

Pregnancy increases the production of estrogen and progesterone in your body. Fibroids may develop and grow rapidly while you’re pregnant.

Women of all races are affected, but fibroids are more common and develop at an earlier age, in women of African origin 2. By age 35 years, 60% of African-American women will have fibroids, compared to 40% in Caucasian women of the same age. Other risk factors include age (increasing incidence with age up to menopause, then usually decreasing in size), nulliparity, genetic factors, early menarche, caffeine, alcohol, obesity, and hypertension 3.

What Are the Symptoms?

Some women may find out they have uterine fibroids because their doctor discovers them during a routine exam or ultrasound.

If you do have symptoms, they might include:

  • Heavy bleeding or painful periods
  • Bleeding between periods
  • Pressure, pain, or fullness in your lower stomach
  • Enlarged abdomen or uterus
  • Constipation
  • Needing to pee often or having trouble emptying your bladder
  • Pain during sex
  • Miscarriage or infertility

 

 

 

 

 

 

 

MANAGEMENT OF FIBROID

Management can be done using

  • Orthodox medications
  • Nutraceuticals

The aims include:

  • Shrink the fibroid
  • Reduce chances of regrowth

However, recent nutraceutical solutions target dissolving the fibroid mass.

[Click here to order your Fibroid Nutraceutical Management Package]

  • MEDICATIONS

Medications for uterine fibroids target hormones that regulate your menstrual cycle, treating symptoms such as heavy menstrual bleeding and pelvic pressure. They don’t eliminate fibroids but may shrink them. Medications include:

  • Gonadotropin-releasing hormone (GnRH) agonists. Medications called GnRH agonists to treat fibroids by blocking the production of estrogen and progesterone, putting you in a temporary menopause-like state. As a result, menstruation stops, fibroids shrink and anemia often improves.

GnRH agonists include leuprolide (Lupron, Eligard, others), goserelin (Zoladex), and triptorelin (Trelstar, Triptodur Kit).

Many women experience significant hot flashes while using GnRH agonists. GnRH agonists typically are used for no more than three to six months because symptoms return when the medication is stopped and long-term use can cause loss of bone.

Your doctor may prescribe a GnRH agonist to shrink the size of your fibroids before planned surgery or to help transition you to menopause.

  • Progestin-releasing intrauterine device (IUD). A progestin-releasing IUD can relieve heavy bleeding caused by fibroids. A progestin-releasing IUD provides symptom relief only and doesn’t shrink fibroids or make them disappear. It also prevents pregnancy.
  • Tranexamic acid (Lysteda, Cyklokapron). This non-hormonal medication is taken to ease heavy menstrual periods. It’s taken only on heavy bleeding days.
  • Other medications
    • Oral contraceptives can help control menstrual bleeding, but they don’t reduce fibroid size.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs), which are not hormonal medications, may be effective in relieving pain related to fibroids, but they don’t reduce bleeding caused by fibroids.
    • Your doctor may also suggest that you take vitamins and iron if you have heavy menstrual bleeding and anemia.
  • NUTRACEUTICALS

Many nutraceuticals use products that dissolve the fibroid mass, regulate the growth of fibroid cells and inhibit the growth of the fibroid mass by functioning as Anti-inflammatory agents, antioxidant and others, some are:

  1. GLUTATHIONE

Hormonal imbalance is the major cause of infertility. The liver removes toxins and balances hormones in the body without glutathione that can’t be done.

Infertility and other female health issues are majorly caused by an imbalance among estrogen and low progesterone a woman can’t conceive.

Excess estrogen and low testosterone results in low sperm count, low libido, and erectile dysfunction in men.

Excess estrogen feed on fibroid in a woman’s body and oxidation stress causes menstrual pains, irregular menstrual periods, and early menopause.

And glutathione is the antidote for oxidant stress and maximum liver function.

Once the liver’s glutathione levels are raised the liver will remove the excess estrogen and balance progesterone and testosterone and the fibroid will SHRINK NATURALLY.

[Click here to order your Fibroid Nutraceutical Management Package]

  • CURCUMIN

Research has revealed that the active ingredient in turmeric, which is responsible for its characteristic colour, odour and most of the medicinal properties, is curcumin. It has potent antioxidantanti-inflammatory, and healing effects that help in curing diseases like cancers including uterine fibroids.

Curcumin has the following properties

1. Inhibitory effect of curcumin on uterine tumor cell proliferation

A human receptor in the cells of several organs called PPAR-Ƴ (peroxisome proliferators – activated receptor – gamma) is involved in inhibition of growth of fibroids.

Curcumin has been shown to be one of the compounds that can bind to and activate PPAR – Ƴ.

In the uterus, curcumin binds to this receptor on the uterine tissue cells and activates it. The activation of PPAR – Ƴ leads to the control of unnecessary growth of the uterine smooth muscle cells and tissues, leading to the healing of fibroids.

What it means: curcumin from turmeric helps in inhibition of the unnecessary and excessive growth of the uterine tissues which helps in controlling uterine leiomyomas or fibroids.

2. Curcumin induces programmed cell death in uterine fibroids

It is usually not enough to stop the growth of tumour cells.

The lumps of tumour that are already present need to be removed as well. Thus it is important to kill these tumour cells to heal the fibroids completely.

In general, our body has its own mechanism to kill cells which are called apoptosis or programmed cell death.

Apoptosis occurs in the cells in case of the presence of any irreparable damage which can turn the cells cancerous or harm neighbouring tissues.

For this purpose, some molecules called pro-apoptotic factors are activated when the cell senses any irreparable damage. Contrary to these, anti-apoptotic factors are activated in the cells which prevent any unnecessary cell death.

Recently, in several clinical investigations, it was revealed that curcumin from turmeric has the ability to induce apoptosis in the cells of uterine fibroids.

Curcumin has been shown to upregulate pro-apoptotic factors in these cells which then undergo autophagy.

Autophagy is a method employed by the cells to commit suicide. They release digestive chemicals and digest their own components, thus undergoing programmed cell death.

Curcumin has been shown to induce apoptosis via autophagy in these cells, controlling the formation of fibroids.

What it means: curcumin induces programmed cell death in the cells forming fibroids or tumours in the uterine fibroids/leiomyosis. This controls and heals the disorder naturally .

3. Curcumin decreases the formation of fibroids in the uterus

Uterine fibroids are tumours in the cells that lead to fibrosis. These cells usually secrete a lot of extracellular matrix components (the molecules that fill up space on the outside of cells).

These components include collagen and other fibrous proteins.

The deposition of these extracellular matrices (ECM) components makes the tissues hard and non-flexible. This is the characteristic of fibrosis.

Curcumin from turmeric has been proven to be a potent inhibitor of fibronectin in the uterine tissues. It not only prevents fibronectin secretion, it also acts as a neoplastic agent which means that it prevents the formation of new cells.

What it means: curcumin helps in inhibiting the production or regulating the production of fibronectin which ultimately helps in controlling the growth of the fibroid tissue and stopping the deposition of extracellular matrix components that makes the fibroids hard.

 [Click here to order your Fibroid Nutraceutical Management Package]

4. Curcumin shows inhibition of development of blood vessels in tumour lumps

Development of blood vessels or angiogenesis is a process in which the tumour cells secrete factors so that the blood vessel formation takes place in it and they get proper oxygen for their survival.

This process is important to make sure that the tumour proliferates properly.

The tumour cells secrete certain growth factors that attract the blood vessels and they outgrow in the region of the cancerous lumps. Inhibiting this process devoid tumour cells of oxygen supply leading to their death.

Studies on curcumin and its effect on reproductive disorders have shown that the compound inhibits the process of angiogenesis or blood vessel development in the extra growth in the uterine tissue.

In other words, it does not allow the blood vessels to grow in the vicinity of tumour cells. It does so by inhibiting the effect of vascular endothelial growth factor, which is an important angiogenic compound that tumour cells make use of, for angiogenesis. Inhibiting VEGF leads to the lack of angiogenesis in fibroid lumps, suffocating them to their death.

What it means: curcumin from turmeric inhibits the growth factors that help in developing blood vessels I the fibroid tissue. This leads to the restraining of oxygen supply to these cells and the tumour cells die .

5. Curcumin acts as an anti-inflammatory agent

Inflammation is one of the important reasons that lead to the alteration of the cells. This alteration causes the abnormal release of growth factors and abnormally high cell division which results in uterine fibroids.

Turmeric has been identified as one of the important dietary phytochemicals that help in the amelioration of inflammation by healing the uterine tissues of any injury or infection.

It also reduces the number of inflammatory molecules circulating in the blood and protects the cells.

[Click here to order your Fibroid Nutraceutical Management Package]

References

  1. Cramer SF, Patel A: The frequency of uterine leiomyomas.Am J Clin Pathol. 1990;94(4):435–8. 10.1093/ajcp/94.4.435 [PubMed] [CrossRef] [Google Scholar]
  2. Baird DD, Dunson DB, Hill MC, et al. : High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence.Am J Obstet Gynecol. 2003;188(1):100–7. 10.1067/mob.2003.99 [PubMed] [CrossRef] [Google Scholar] F1000 Recommendation
  3. Donnez J, Dolmans M: Uterine fibroid management: from the present to the future.Hum Reprod Update. 2016;22(6):665–86. 10.1093/humupd/dmw023 [PMC free article] [PubMed] [CrossRef] [Google Scholar]

https://www.healthline.com/health/uterine-fibroids#treatment

Comments (2)

  • Pedroginna Reply

    Not so long ago, I have ordered some items in your store. I paid for the order immediately, but I did not receive any confirmation about the order yet. Today a week passed already. My goods have not been delivered. Must I make a refund request? I’ve ordered a gift for my wife, but received nothing! Who can solve my problem?

    e-mail
    alicia@bostdorf.net

    June 30, 2020 at 6:52 am
    • admin Reply

      We have not seen any evidence of payment from you. Can you specify what you ordered for and your order number

      July 1, 2020 at 12:56 pm

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